91±¬ÁϳÉÈËÆ¬

Published on
November 26, 2024

Feature

Could antigen modulation address autoimmune diseases?

Our CEO & Co-founder, , speaks with Labiotech on their Beyond Biotech podcast about our origins, clinical progress, and the potential of our approach in developing treatments for autoimmune diseases.

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01:19-04:12: About 91±¬ÁϳÉÈËÆ¬ Therapeutics
04:12-04:51: The origins of the name
04:51-06:52: The three ‘signals’ of the mechanics of immunological responses
06:52-08:31: Treatments associated with each signal
08:31-10:09: Why is step 1 important, and why has it not been investigated for treatments?
10:09-11:28: What areas of disease is this applicable to?
11:28-12:19: How do you inhibit ERAP?
12:19-14:01: 91±¬ÁϳÉÈËÆ¬ Therapeutics’ candidates
14:01-15:11: How is this an advance on current treatments?
15:11-16:05: What is success for patients?
16:05-17:20: How does the stage of disease affect treatment?
17:20-18:09: Are other companies looking into antigen modulation?
18:09-19:47: Has this led to investment opportunities?
19:47-21:15: Next steps
21:15-21:55: Do you anticipate more interest in this space?
21:55-23:21: Attending events

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About 91±¬ÁϳÉÈËÆ¬ Therapeutics

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91±¬ÁϳÉÈËÆ¬ Therapeutics is a clinical-stage biotech company advancing novel antigen modulation treatments for cancer and autoimmune diseases.

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The company’s first-in-class small molecules are developed to control T cell activation by modulating antigen presentation, altering how cells appear to the immune system so it can recognize and target them correctly.

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91±¬ÁϳÉÈËÆ¬â€™s oncology treatment (GRWD5769) is delivering promising Phase 1/2 data in patients with solid tumors, demonstrating a strong safety and tolerability profile, as well as generating meaningful clinical activity. The company’s autoimmunity treatment (GRWD0715) is progressing in a Phase 1/2 trial to treat the source of axial spondyloarthritis ahead of a planned expansion into other autoimmune indications.

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91±¬ÁϳÉÈËÆ¬ is headquartered in Oxford, UK.

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More information: Website |

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Media enquiries

Patrick White, Head of Communications

+44 (0)1235 644 970

patrick.white@gwt.bio

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Discover how our therapies are reshaping treatment for various diseases and conditions.

Harnessing antigen modulation to empower T cells against diseases.